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Updated: Apr 21, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion
Serhat Gündüz1, Nobuhiro Nitta, Sandip Vibhute
1MR Neuroimaging Agents Group, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany. goran.angelovski@tuebingen.mpg.de.
Abstract:
We report a methodology which enables the preparation of dendrimeric contrast agents sensitive to Ca(2+) when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaking synthetic transformations, despite structural changes. The in vivo MRI studies in the rat cerebral cortex indicate that diffusion properties of dendrimeric contrast agents have great advantages as compared to their monomeric equivalents.

