(-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β
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Updated: Apr 21, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Ifedayo Victor Ogungbe1, Rebecca A Crouch, Teresa Demeritte
1Department of Chemistry and Biochemistry, Jackson State University , Jackson, Mississippi 39217, United States.
Abstract:
Lignans are important biologically active dietary polyphenolic compounds. Consumption of foods that are rich in lignans is associated with positive health effects. Using modeling tools to probe the ligand-binding pockets of molecular receptors, we found that lignans have high docking affinity for the human thyroid hormone receptor β. Follow-up experimental results show that lignans (-) arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β. The modeled complexes show key plausible interactions between the two ligands and important amino acid residues of the receptor.
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