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Bupropion XL-induced motor and vocal tics
Fatih Kayhan1, Faruk Uguz, Ayşegül Kayhan
1*Department of Psychiatry, Mevlana University Faculty of Medicine; †Department of Psychiatry, Necmettin Erbakan University Faculty of Medicine; ‡Department of Radiology, Konya Training and Research Hospital; and §Department of Neurology, State Hospital of Beysehir, Konya, Turkey.
Clinical Neuropharmacology
|November 11, 2014
Summary
Bupropion extended-release (XL) may cause new-onset motor and vocal tics in some patients. This case report highlights a potential adverse effect of this antidepressant medication.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Tics are involuntary motor or vocal stereotypies.
- Selective serotonin reuptuptake inhibitors (SSRIs) have been linked to tic emergence in rare instances.
- Bupropion extended-release (XL) is an antidepressant with a different mechanism of action than SSRIs.
Observation:
- A case report details a male patient prescribed bupropion XL.
- The patient developed both motor and vocal tics after initiating bupropion XL treatment.
- This represents a novel observation linking bupropion XL to tic development.
Findings:
- The emergence of motor and vocal tics was observed during bupropion XL therapy.
- This contrasts with previous reports primarily associating tics with SSRI use.
- The findings suggest bupropion XL may be an underrecognized cause of iatrogenic tics.
Implications:
- Clinicians should consider bupropion XL as a potential cause of new-onset tics.
- Further research is warranted to investigate the incidence and mechanisms of bupropion-induced tics.
- This case expands the understanding of potential neuropsychiatric side effects of bupropion XL.
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