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Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes.

Menna R Clatworthy1, Caren E Petrie Aronin2, Rebeccah J Mathews3

  • 11] Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, UK. [2] Laboratory of Systems Biology, Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Nature Medicine
|November 11, 2014
PubMed
Summary

Immune complexes (ICs) containing IgG antibodies stimulate dendritic cell (DC) migration to lymph nodes. This process, dependent on chemokine receptor 7 (CCR7), may contribute to autoimmune diseases like lupus.

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