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Unexpected overestimation of methotrexate plasma concentrations: importance of the assay implementation and its

Maaike Godefroid1, Alain G Verstraete, Veronique Stove

  • 1*Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium †Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.

Therapeutic Drug Monitoring
|November 11, 2014
PubMed
Abstract

No abstract available in PubMed .

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Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
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