The human mycobiome

Area of Science:

• Microbiology
• Human Physiology
• Medical Mycology

Background:

• The human microbiome, comprising bacteria, viruses, and fungi, significantly influences human physiology.
• Fungi, collectively termed the mycobiome, are integral components of this microbial ecosystem.
• Understanding the mycobiome is crucial for comprehending host-microbe interactions and overall health.

Purpose of the Study:

• To provide a comprehensive review of the current knowledge on the human mycobiome.
• To highlight methodologies for studying the mycobiome.
• To discuss the mycobiome's diversity, dynamics, and role in human health and disease.

Main Methods:

• Literature review of existing studies on the human mycobiome.
• Analysis of research methodologies for mycobiome investigation.
• Synthesis of data on mycobiome diversity across different body sites and its changes during life stages.

Main Results:

• The mycobiome exhibits significant diversity across various human body sites.
• Fungal communities change dynamically throughout human development, health, and disease states.
• Early research indicates complex interactions between the mycobiome, other microbes, and the host.

Conclusions:

• The human mycobiome is a critical factor in maintaining health and influencing disease pathogenesis.
• Further research into mycobiome composition and function is essential for developing novel therapeutic strategies.
• The mycobiome's role in host physiology, immunity, and neurological functions warrants continued investigation.