Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.7K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.7K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Finger iridectomy technique (FIT): anterior segment uveal melanoma biopsy.

Journal of visualized surgery·2026
Same author

Palladium-103 plaque radiation therapy for retinal angioma.

American journal of ophthalmology case reports·2025
Same author

Intravitreal fluocinolone acetonide 0.19 mg Iluvien implant for radiation maculopathy.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2025
Same author

RWC Update: Pars Plana Vitrectomy for Symptomatic Vitreous Floaters; Subretinal Hemorrhage; Epiretinal Membrane With Lamellar Defects.

Ophthalmic surgery, lasers & imaging retina·2025
Same author

Towards Accountable AI in Eye Disease Diagnosis: Workflow, External Validation, and Development.

ArXiv·2025
Same author

Retinal progenitor cells (jCell) for retinitis pigmentosa.

Frontiers in cellular neuroscience·2025

Related Experiment Video

Updated: Apr 21, 2026

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
06:46

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

1.6K

Angled transscleral intravitreal injection: a crossover study.

Mitul C Mehta1, Paul T Finger

  • 1The New York Eye Cancer Center, New York - USA.

European Journal of Ophthalmology
|November 12, 2014
PubMed
Summary
This summary is machine-generated.

Orthogonal intravitreal injections cause less intraocular pressure rise than oblique injections. Angled entries may improve medication delivery and reduce reflux, but increase pressure.

More Related Videos

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

2.0K
An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
07:13

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

14.1K

Related Experiment Videos

Last Updated: Apr 21, 2026

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
06:46

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

1.6K
Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

2.0K
An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
07:13

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

14.1K

Area of Science:

  • Ophthalmology
  • Surgical Techniques
  • Drug Delivery

Background:

  • Intravitreal injections are crucial for delivering medication to the eye.
  • Optimizing injection technique minimizes risks and maximizes therapeutic efficacy.
  • Understanding fluid dynamics and ocular response is key to safe injections.

Purpose of the Study:

  • To compare two intravitreal injection methods: orthogonal (straight) and oblique (angled).
  • To determine if angled transscleral entry reduces intravitreal content egress.
  • To assess the impact of injection angle on intraocular pressure (IOP) and medication delivery.

Main Methods:

  • A crossover controlled trial involving 10 patients.
  • Each patient received 0.05 mL bevacizumab via both orthogonal and oblique techniques in different eyes.
  • Intraocular pressure (IOP) was measured pre- and post-injection monthly.

Main Results:

  • Orthogonal injections resulted in a significantly lower IOP rise (mean 24.6 mm Hg) compared to oblique injections (mean 29.6 mm Hg) (p = 0.045).
  • No significant differences in injection-related pain or adverse events were observed between techniques.
  • Oblique injections led to a greater percentage increase in IOP.

Conclusions:

  • Oblique or angled intravitreal injections cause a greater increase in intraocular pressure than orthogonal injections.
  • Angled injections may offer benefits such as self-sealing, improved medication retention, and reduced pathogen entry.
  • Further research is needed to fully elucidate the clinical implications of angled versus straight intravitreal injections.