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Renal cell carcinoma.

Eric Jonasch1, Jianjun Gao2, W Kimryn Rathmell3

  • 1Department of GU Medical Oncology, MD Anderson Cancer Center, Houston, TX 77230-1439, USA ejonasch@mdanderson.org.

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|November 12, 2014
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Summary
This summary is machine-generated.

Recent advancements in renal cell carcinoma (RCC) treatment include improved surgical techniques for primary tumors and new systemic therapies targeting tumor growth. Immunotherapy shows promise for advanced RCC.

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Area of Science:

  • Oncology
  • Nephrology
  • Genitourinary Cancer

Background:

  • Renal cell carcinoma (RCC) treatment has evolved significantly over 15 years.
  • Progress driven by surgical advancements and molecular/genomic understanding.
  • New therapeutic agents have emerged for advanced disease.

Purpose of the Study:

  • To review prospective randomized phase III studies on RCC management.
  • To provide an updated summary of RCC histology, genomics, staging, and prognosis.
  • To outline current surgical and systemic treatment strategies for RCC.

Main Methods:

  • Systematic review of prospective randomized phase III studies.
  • Analysis of data on surgical management and systemic therapies.
  • Summary of current knowledge on RCC characteristics and prognosis.

Main Results:

  • Surgical management emphasizes achieving clean margins for primary tumors and enhanced partial nephrectomy safety.
  • Advanced RCC treatment now includes agents targeting tumor vasculature and oncogenic pathways.
  • Immunomodulatory agents represent a promising new therapeutic class for advanced RCC.

Conclusions:

  • Surgical approaches for primary RCC have been refined for efficacy and safety.
  • Systemic therapies have dramatically improved outcomes for advanced RCC.
  • Immunotherapy holds significant potential for future advanced RCC treatment paradigms.