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Platelet Counts in Children With Henoch-Schonlein Purpura--Relationship to Renal Involvement

Ahmet Taner Elmas1, Yilmaz Tabel1

  • 1Department of Pediatric Nephrology, Faculty of Medicine, University of Inonu, Malatya, Turkey.

Journal of Clinical Laboratory Analysis
|November 12, 2014
PubMed

Insights

Age, sex, gastrointestinal issues, and high platelet counts are key indicators for kidney problems in Henoch-Schönlein purpura (HSP) patients. Early identification of these risk factors aids in predicting and managing renal involvement in children with HSP.

Area of Science:

  • Pediatric Nephrology
  • Rheumatology
  • Clinical Immunology

Background:

  • Henoch-Schönlein purpura (HSP) is a common vasculitis in children.
  • Renal involvement is a significant complication of HSP, affecting up to 26.1% of patients.
  • Identifying risk factors for renal involvement is crucial for timely management.

Purpose of the Study:

  • To identify clinical and laboratory risk factors for renal involvement in pediatric HSP patients.
  • To determine the relationship between platelet counts and renal involvement in HSP.
  • To assess the predictive value of platelet count for renal complications.

Main Methods:

  • Retrospective review of medical records for 107 children diagnosed with HSP.
  • Evaluation of clinical and laboratory parameters, including platelet counts.
  • Comparison of parameters between patients with and without renal involvement using multivariate logistic regression analysis.

Main Results:

  • The mean platelet count was significantly higher in patients with renal involvement (P = 0.001).
  • Age, sex, gastrointestinal involvement, and platelet count were identified as significant risk factors for renal involvement (P < 0.05).
  • Platelet count demonstrated predictive value for renal involvement (AUC = 0.66, P = 0.009).

Conclusions:

  • Age, sex, gastrointestinal involvement, and platelet count are significant risk factors for renal involvement in HSP.
  • Elevated platelet counts may indicate an increased risk of kidney complications in children with HSP.
  • These factors can aid in the early detection and management of renal complications in HSP.
Abstract

Keywords:
Henoch-Schönlein purpurachildplatelet countsrenal involvement

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