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Hepatitis B vaccination during pregnancy for preventing infant infection

Ussanee S Sangkomkamhang1, Pisake Lumbiganon, Malinee Laopaiboon

  • 1Department of Obstetrics and Gynaecology, Khon Kaen Hospital, Srichan Road, Maung, Khon Kaen, Thailand, 40000.

The Cochrane Database of Systematic Reviews
|November 12, 2014
PubMed

Insights

No randomized controlled trials (RCTs) were found on hepatitis B vaccination for pregnant women to prevent infant infection. More research is needed to guide clinical practice and assess vaccine safety and effectiveness.

Area of Science:

  • Perinatal infectious disease prevention
  • Vaccinology
  • Maternal and infant health

Background:

  • Infant hepatitis B infection poses risks of chronic illness, cirrhosis, and liver cancer.
  • Perinatal transmission is a significant route for hepatitis B virus (HBV) infection in newborns.

Purpose of the Study:

  • To evaluate the efficacy and safety of administering hepatitis B vaccine to pregnant women.
  • To determine the effectiveness of maternal hepatitis B vaccination in preventing infant HBV infection.

Main Methods:

  • Searched the Cochrane Pregnancy and Childbirth Group's Trials Register for relevant studies.
  • Included only randomized controlled trials (RCTs) comparing hepatitis B vaccination with placebo or no treatment during pregnancy.
  • Excluded quasi-RCTs and cross-over studies.

Main Results:

  • No eligible randomized controlled trials (RCTs) were identified in the search.
  • The review could not include any studies to analyze.

Conclusions:

  • There is a lack of RCTs evaluating hepatitis B vaccination in pregnant women for infant protection.
  • Current evidence does not support clinical practice guidelines in this area.
  • Well-designed RCTs are necessary to assess the impact of maternal hepatitis B vaccination on infant infection rates and maternal/infant safety.
Abstract

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