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Related Concept Videos

Allosteric Regulation01:08

Allosteric Regulation

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Allosteric regulation of enzymes occurs when the binding of an effector molecule to a site that is different from the active site causes a change in the enzymatic activity. This alternate site is called an allosteric site, and an enzyme can contain more than one of these sites. Allosteric regulation can either be positive or negative, resulting in an increase or decrease in enzyme activity. Most enzymes that display allosteric regulation are metabolic enzymes involved in the degradation or...
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Altruistic behaviors are “unselfish” behaviors—those that help another individual at the expense of the individual carrying out the behavior. Despite the negative consequences for the altruistic animal, these behaviors are thought to have evolved for several reasons.
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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
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BioMEMS and Cellular Biology: Perspectives and Applications
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Reply to L. Alonso et al

Jean-François Brasme1, Martin Chalumeau2, Odile Oberlin3

  • 1Inserm U1153, Center for Epidemiology and Statistics Sorbonne Paris Cité; Hôpital Necker-Enfants Malades; Paris Descartes University, Paris; and Institut Gustave Roussy, Villejuif; Université Paris Sud, Le Kremlin Bicêtre, France jean-francois.brasme@inserm.fr.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|November 12, 2014
PubMed
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No abstract available in PubMed .

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