Related Experiment Video
Updated: Apr 21, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Effect of chronic kidney disease on serum resistin level
1Department of Biochemistry, Calcutta Medical College, Kolkata, India.
Background:
Chronic Kidney Diseases (CKD) of all etiologies are usually associated with Insulin Resistance (IR). Resistin is also a protein associated with IR. Some studies conducted abroad have shown that resistin level is higher among CKD patients.
Objective:
To test if serum resistin level is significantly higher in CKD patients compared to normal individuals.
Patients And Methods:
96 CKD patients and 97 normal individuals were included in the study. Written informed consent was obtained from every individual.
Results:
Serum resistin level was higher in CKD patients compared to control subjects. The difference in serum resistin level between two groups was statistically significant.
Conclusion:
Our study is probably the first study in India comparing serum resistin levels of CKD patients vis-à-vis control subjects. Further cellular research may be needed to explore this relation.
Related Concept Videos
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Chronic Kidney Disease I: Introduction
Chronic Kidney Disease II: Clinical Manifestations
Serum Studies: Renal Function Tests
Chronic Kidney Disease III: Interprofessional Care
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

