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Tight junctions in Hailey-Hailey and Darier's diseases

Laura Raiko1, Pekka Leinonen2, Päivi M Hägg3

  • 1Department of Dermatology, University of Turku and Turku University Central Hospital, Turku, Finland;

Dermatology Reports
|November 12, 2014
PubMed
Summary

Tight junctions (TJ) maintain skin barrier function. In Hailey-Hailey disease and Darier's disease, TJ proteins show altered distribution, impacting epidermal barrier integrity and increasing water loss.

Keywords:
Darier-White diseaseadherens junctionclaudintight junctionzonula occludens protein 1.

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