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Related Experiment Video

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Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth

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Interrelationship between type three secretion system and metabolism in pathogenic bacteria.

Gottfried Wilharm¹, Christine Heider¹

¹Project Group P2, Robert Koch-Institute Wernigerode, Germany.

Frontiers in Cellular and Infection Microbiology

|November 12, 2014

Summary

Pathogen virulence factors, like type three secretion systems (T3SSs), are closely linked to their metabolism. This review explores the intricate connection between T3SSs and pathogen metabolic functions during infection.

Keywords:

Pseudomonas Salmonella T3SS Yersinia cross-talk metabolism type three secretion system virulence

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Area of Science:

Microbiology
Molecular Biology
Infectious Diseases

Background:

Historically, pathogen studies focused on metabolism, shifting to molecular biology for virulence factor identification.
Genomic and proteomic approaches offer systemic views of pathogen functions in infection.
There is a renewed focus on pathogen and host metabolism, revealing complex interactions.

Purpose of the Study:

To review the intertwined relationship between type three secretion systems (T3SSs) and pathogen metabolism.
To highlight T3SSs as key virulence determinants in Gram-negative pathogens.

Main Methods:

Literature review focusing on studies investigating T3SSs and pathogen metabolism.
Analysis of genomic, proteomic, and metabolic data related to T3SS-possessing pathogens.

Main Results:

T3SSs, crucial for virulence, are significantly influenced by and influence pathogen metabolic pathways.
Metabolic status impacts the expression and function of T3SSs, affecting infection dynamics.

Conclusions:

The metabolism of pathogens is intrinsically linked to the function of major virulence factors like T3SSs.
Understanding this interplay is crucial for developing novel anti-infective strategies targeting pathogen metabolism and virulence.