Partial versus complete fundoplication for the correction of pediatric GERD: a systematic review and meta-analysis

Peter Glen1, Michaël Chassé2, Mary-Anne Doyle3

  • 1University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.

Plos One
|November 12, 2014
PubMed

Insights

Current evidence does not show a difference in surgical success between complete (360-degree) and partial fundoplication for gastroesophageal reflux disease (GERD). Further high-quality research is needed to compare these surgical techniques for GERD management.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Surgical Outcomes

Background:

  • The optimal extent of fundoplication for gastroesophageal reflux disease (GERD) in children remains debated.
  • Lack of consensus exists regarding the required degree of fundic wrap for effective GERD correction.

Purpose of the Study:

  • To compare the efficacy of complete (360-degree) versus partial fundoplication in controlling GERD.
  • To evaluate secondary outcomes including dysphagia and complications associated with different fundoplication techniques.

Main Methods:

  • Systematic literature search of MEDLINE and Scopus for studies on pediatric fundoplication.
  • Inclusion of randomized controlled trials (RCTs) and observational studies comparing surgical techniques.
  • Meta-analysis of pooled data and assessment of study quality using the Cochrane Risk of Bias Tool.

Main Results:

  • Two RCTs and 12 cohort studies were included; RCTs showed no significant difference in surgical success between partial and complete fundoplication (OR 1.33 [0.67, 2.66]).
  • Cohort studies exhibited heterogeneity, with limited objective surgical assessment; one study suggested better outcomes with complete fundoplication.
  • Common complications included dysphagia and gas-bloat syndrome; overall study quality was poor.

Conclusions:

  • Current evidence is insufficient to demonstrate the superiority of either partial or complete fundoplication for GERD.
  • Further high-quality randomized controlled trials are necessary to definitively compare these surgical approaches.
  • Methodological limitations and heterogeneity in existing studies hinder robust meta-analysis and definitive conclusions.
Abstract

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