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Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant
Marc Folcher1, Sabine Oesterle1, Katharina Zwicky1
1Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
Nature Communications
|November 12, 2014
Summary
Scientists developed a mind-controlled gene switch using brain waves to wirelessly program gene expression. This brain-computer interface controls transgene expression in cells and implants, offering future therapeutic potential.
Area of Science:
- Synthetic biology
- Neuroscience
- Biotechnology
Background:
- Gene expression control is crucial for gene and cell therapies.
- Remote, traceless control systems are needed for advanced therapeutic applications.
Purpose of the Study:
- To design a synthetic gene switch controlled by human brain activity.
- To enable wireless programming of transgene expression via a brain-computer interface.
Main Methods:
- Utilized an electroencephalography (EEG)-based brain-computer interface (BCI) to decode mental states.
- Developed an optogenetic implant with designer cells responsive to near-infrared (NIR) light.
- Engineered a synthetic signaling pathway involving bacterial diguanylate cyclase (DGCL) and cyclic diguanosine monophosphate (c-di-GMP).
Main Results:
- Demonstrated differential control of SEAP (secreted alkaline phosphatase) production by varying mental states.
- Successfully programmed transgene expression in cultured cells and in vivo using wireless optogenetic implants.
- Showcased control via biofeedback, concentration, and meditation.
Conclusions:
- A synthetic mind-controlled gene switch was successfully developed and demonstrated.
- This technology enables wireless, brain-activity-driven gene expression control.
- Presents a novel platform for future gene and cell-based therapies.
