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Genetically engineered pig models for human diseases.

Randall S Prather1, Monique Lorson, Jason W Ross

  • 1Division of Animal Science, National Swine Resource and Research Center, and.

Annual Review of Animal Biosciences
|November 12, 2014
PubMed
Summary
This summary is machine-generated.

Genetically engineered pigs are advancing human disease research. Advanced genetic engineering technologies enable the creation of precise animal models for studying complex conditions like Alzheimer's and diabetes.

Keywords:
cloninggenetic engineeringswine

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Area of Science:

  • Biomedical Science
  • Genetics
  • Animal Models

Background:

  • Pigs are valuable models for human disease research.
  • Traditional genetic modification methods had limitations.

Purpose of the Study:

  • To review the advancements in genetically engineered pigs as models for human diseases.
  • To highlight the potential of these models for understanding and treating diseases.

Main Methods:

  • Application of homologous recombination.
  • Utilizing zinc finger nucleases (ZFNs).
  • Employing transcription activator-like effector nuclease (TALEN) technologies.

Main Results:

  • Genetic engineering allows precise modifications in pigs.
  • New models are available for diseases lacking adequate animal models.
  • These models facilitate the study of Alzheimer's, cystic fibrosis, diabetes, and organ failure.

Conclusions:

  • Genetically engineered pigs offer unprecedented opportunities for biomedical research.
  • These advanced animal models are crucial for preclinical studies and therapeutic development.
  • Further research with these models will uncover new insights into human diseases.