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Gene regulation and DNA C-value paradox: a model based on diffusion of regulatory molecules
1UER D'Hematologie, LOI CNRS, Institut de Recherche sur les Maladies du Sang, Hopital St Louis, Paris, France.
Medical Hypotheses
|January 1, 1989
Abstract:
The general idea of the model is that regulatory molecules can move stochastically from site to site along DNA and that according to their chromosomal position, genes should have a more or less high probability to be activated (or repressed) during differentiation. In this model the role of non coding DNA is to maintain genes in a relative position that determines what is usually called the "differentiation programme".