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Genetics, neuroscience, and psychopathology: clothing the emperor
1Department of Psychology, Florida State University, Tallahassee, Florida, USA.
Abstract:
This ground-breaking series of articles reports findings from genome-wide analyses of endophenotypic indicators of psychopathology including electrocortical activity/reactivity, electrodermal and startle blink responses, and neurocognitive task performance. Findings challenge the long-held notion that endophenotypes more clearly reflect the impact of specific genes than referent clinical phenotypes. Implications for the concept of endophenotypes and biological psychopathology research more broadly are discussed.
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