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Rapid Generation of Amyloid from Native Proteins In vitro
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Extended structure of rat islet amyloid polypeptide in solution

Lei Wei1, Ping Jiang, Malathy Sony Subramanian Manimekalai

  • 1School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, Singapore.

Advances in Experimental Medicine and Biology
|November 13, 2014
PubMed
Summary

Rat islet amyloid polypeptide (rIAPP) was studied to understand its structure. Researchers used SAXS, NMR, and MD simulations to reveal its extended, random-coiled shape in solution, aiding research into pancreatic beta-cell dysfunction.

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