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Increase of circulating stromal cell-derived factor-1 in heart failure patients

K Liu1, S Yang, M Hou

  • 1Key Laboratory of Myocardial Ischemia Mechanism and Treatment, Chinese Ministry of Education, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086, Harbin, Heilongjiang Province, China.

Herz
|November 13, 2014
PubMed

Insights

Circulating stromal cell-derived factor-1 (SDF-1) levels are elevated in hospitalized heart failure (HHF) patients. Higher SDF-1 correlates with poorer heart function and increased inflammation markers.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • The role of circulating stromal cell-derived factor-1 (SDF-1) in heart failure (HF) remains undefined.
  • This study investigates SDF-1 levels in patients hospitalized with heart failure (HHF).

Purpose of the Study:

  • To determine circulating SDF-1 levels in HHF patients.
  • To explore correlations between SDF-1 and established HF biomarkers.

Main Methods:

  • Measured circulating SDF-1, N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and echocardiographic parameters.
  • Compared HHF patients (n=69) with healthy controls (n=35).

Main Results:

  • HHF patients exhibited significantly higher SDF-1 levels (5,101 pg/ml) than controls (1,879 pg/ml).
  • SDF-1 positively correlated with NT-proBNP (r=0.46) and CRP (r=0.53).
  • SDF-1 negatively correlated with left ventricular ejection fraction (r=-0.41).

Conclusions:

  • Circulating SDF-1 levels are elevated in HHF patients.
  • SDF-1 may serve as a biomarker for heart failure severity and inflammation.
Abstract

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