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Updated: Apr 21, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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A beginners guide to estimating the non-synonymous to synonymous rate ratio of all protein-coding genes in a genome

Daniel C Jeffares1, Bartłomiej Tomiczek, Victor Sojo

  • 1Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK, d.jeffares@ucl.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)
|November 13, 2014
PubMed

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