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Human mast cell and basophil/eosinophil progenitors

Gail M Gauvreau1, Judah A Denburg

  • 1McMaster University, HSC-3U26, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1, gauvreau@mcmaster.ca.

Methods in Molecular Biology (Clifton, N.J.)
|November 13, 2014
PubMed

Mast cell, basophil, and eosinophil lineages all derive from CD34(+) hemopoietic stem cells; however, mast cells are derived from a distinct, nonmyeloid progenitor, while eosinophils and basophils share a common myeloid progenitor. These progenitors likely evolved from an ancestral leukocyte population involved in innate immunity and currently play a central role in the pathology of allergic disease. Advances in isolation and analysis of mast cell and basophil/eosinophil progenitor populations have been critical to understanding lineage commitment, differentiation, function, and transcriptional regulation of these cells and have provided a way of monitoring the effect of novel investigational therapies on these cell populations in samples of blood, bone marrow, and airway secretions.

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