Modification of adrenergic and vasopressin receptor-linked lipid metabolism during endotoxemia

Our studies addressing various aspects of lipid metabolism linked to the activation of alpha 1-adrenergic and vasopressin receptors suggest the following conclusions: 1) Adjustments in lipid metabolic flux seem to compensate for catabolic processes known to be triggered by endotoxin; 2) the diminished DG signal generation for vasopressin1 receptor-linked transduction mechanisms is likely to underlie some concomitant functional impairments and 3) defective acylation of AA may contribute to cellular metabolic perturbations by affecting the turnover of PI, a phospholipid involved in signal transmission, and leading to increased availability of AA for eicosanoid synthesis.