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Metabonomic profiling of bladder cancer
Eric Chun Yong Chan1, Kishore Kumar Pasikanti, Yanjun Hong
1Department of Pharmacy, Faculty of Science, National University of Singapore , 18 Science Drive 4, Singapore 117543, Singapore.
Journal of Proteome Research
|November 13, 2014
Summary
Metabonomics offers a promising noninvasive approach for early bladder cancer detection and lifelong surveillance. This technique identifies metabolic changes, aiding in diagnosis and potentially guiding future treatment strategies.
Area of Science:
- Biochemistry
- Oncology
- Biomarker Discovery
Background:
- Early diagnosis and lifelong surveillance are crucial for improving bladder cancer patient survival.
- Current diagnostic methods lack noninvasive biomarkers with the sensitivity and specificity of cystoscopy.
- Metabonomics (metabolomics) provides a complementary approach to identify metabolic pathways altered in bladder cancer.
Purpose of the Study:
- To review the application of metabonomics in bladder cancer research.
- To highlight the potential of metabonomics for biomarker discovery in bladder cancer.
- To discuss the future impact of metabonomics on clinical management and patient stratification.
Main Methods:
- Utilizing modern metabonomic techniques to analyze metabolic profiles.
- Characterizing and distinguishing bladder cancer patients from healthy controls.
- Identifying specific metabolites indicative of bladder cancer.
Main Results:
- Metabonomics has demonstrated success in differentiating bladder cancer patients from controls.
- Key marker metabolites have been identified through metabonomic investigations.
- Insights into bladder cancer biology and potential therapeutic targets have been gained.
Conclusions:
- Metabonomics shows significant potential for revolutionizing bladder cancer diagnosis and surveillance.
- This approach can aid in stratifying patients for clinical trials.
- Further development of metabonomics may lead to improved clinical management strategies for bladder cancer.
