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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
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[Moebius syndrome and narcolepsy]
S Krämer1, U Goldammer, E Sindern
1Neurologische Klinik des Diakoniekrankenhauses Friederikenstift, Humboldtstr. 5, 30169, Hannover, Deutschland, stefan_kraemer87@me.com.
Der Nervenarzt
|November 13, 2014
Summary
Moebius syndrome patients frequently experience parasomnias. This case highlights narcolepsy cataplexy in Moebius syndrome, emphasizing detailed parasomnia diagnosis through hypocretin levels.
Area of Science:
- Neurology
- Sleep Medicine
Context:
- Moebius syndrome is a rare neurological disorder.
- A frequent association exists between Moebius syndrome and parasomnias.
Purpose:
- To report a case of Moebius syndrome presenting with narcolepsy cataplexy syndrome.
- To illustrate the diagnostic process for parasomnia in Moebius syndrome.
Summary:
- A patient with Moebius syndrome exhibited narcolepsy cataplexy symptoms.
- Cranial MRI revealed brainstem hypoplasia, a morphological correlate of Moebius syndrome.
- Diagnosis was confirmed by cognitive tests, polysomnography, and low cerebrospinal fluid hypocretin levels (132 pg/ml).
- Despite normal sleep onset latency and limited REM episodes, the diagnosis was established.
Impact:
- Highlights the importance of thorough parasomnia evaluation in Moebius syndrome patients.
- Demonstrates the utility of hypocretin level measurement in diagnosing narcolepsy cataplexy.
- Contributes to understanding the neurological underpinnings of sleep disorders in rare genetic conditions.
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