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Updated: Apr 21, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Bilateral central retinal vein occlusion in a young person with storm syndrome
Srinivas R Sadda1, Pearse A Keane
1From the Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Purpose:
To report the presence of previously undescribed retinal abnormalities in patients with Storm and other progeric syndromes.
Methods:
Review of the clinical and photographic records of a patient with Storm syndrome who developed bilateral central retinal vein occlusion.
Results:
A 43-year-old woman with a diagnosis of Storm (Werner-like) syndrome, a connective tissue disease characterized by premature aging, presented with bilateral nonsimultaneous central retinal vein occlusion. The patient was also observed to have bilateral peripheral retinal pigment epithelial alterations.
Conclusion:
Retinal abnormalities can be observed in patients with premature aging syndromes. These abnormalities include the development of venous occlusive disease and peripheral retinal pigment epithelial alterations at a relatively young age and may be related to the underlying genetic mutation.
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