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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

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Diffuse retinal capillary leakage in coats disease.

Ron Margolis¹, Francisco A Folgar, Magdy Moussa

¹*Vitreous-Retina-Macula Consultants of New York, New York, New York †Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, New York, New York ‡Department of Ophthalmology, Tanta University, Tanta, Egypt.

Retinal Cases & Brief Reports

|November 13, 2014

Summary

Coats disease can cause leakage from normal retinal capillaries. Treating the primary vascular lesions in Coats disease effectively resolved this diffuse leakage, preserving healthy capillaries.

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Area of Science:

Ophthalmology
Retinal Vascular Diseases

Background:

Coats disease involves abnormal retinal blood vessels (telangiectasia, aneurysms) leading to leakage.
This condition can present with diffuse hyperpermeability from even normal-appearing capillaries.

Purpose of the Study:

To describe the phenomenon and treatment of Coats disease presenting with diffuse hyperpermeability from angiographically normal retinal capillaries.
To evaluate treatment strategies for this specific presentation of Coats disease.

Main Methods:

A case series of two patients diagnosed with Coats disease using fundus photography and fluorescein angiography.
Treatment involved intravitreal bevacizumab and limited laser photocoagulation in one patient, and limited photocoagulation alone in the other.

Main Results:

Diffuse exudation from normal retinal capillaries resolved following treatment targeting the primary vascular abnormalities of Coats disease.
Both treatment approaches led to the resolution of diffuse leakage.

Conclusions:

Coats disease, a vasculopathy, can manifest as diffuse hyperpermeability in otherwise normal retinal capillaries.
Targeting only the primary Coats lesions offers a minimally invasive treatment strategy that preserves normal capillaries.