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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
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Gadolinium-associated plaques: a new, distinctive clinical entity
Robert M Gathings1, Raveena Reddy2, Daniel Santa Cruz3
1University of Mississippi Medical Center, Jackson.
JAMA Dermatology
|November 13, 2014
Summary
Gadolinium-associated plaques (GAP) are a new skin condition linked to gadodiamide contrast dye. These plaques can appear without nephrogenic systemic fibrosis (NSF) or kidney disease.
Area of Science:
- Dermatology
- Radiology
- Nephrology
Background:
- Gadolinium-based contrast agents (GBCAs) are widely used in radiologic studies.
- Gadodiamide is a specific GBCA associated with adverse skin reactions.
- Nephrogenic systemic fibrosis (NSF) is a known complication of GBCAs in patients with renal disease.
Observation:
- Two patients presented with erythematous plaques, some pruritic, others asymptomatic.
- Histopathology revealed eosinophilic, collagenous bodies in various stages of calcification.
- These sclerotic bodies were previously considered pathognomonic for NSF.
Findings:
- Neither patient had NSF, and only one had pre-existing renal disease.
- The patient without renal disease received high doses of gadodiamide.
- Sclerotic bodies were observed in both patients, indicating a link to gadolinium exposure.
Implications:
- Gadolinium-associated plaques (GAP) can occur independently of NSF and renal disease.
- Physicians should consider GAP in patients with unexplained skin plaques after exposure to gadodiamide.
- The presence of sclerotic bodies in GAP broadens their diagnostic significance beyond NSF.
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