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Multifocal choroiditis in siblings.

Jonathan P Levine1, K Bailey Freund, Michael J Cooney

  • 1From the *Department of Ophthalmology, New York University Medical Center, and †Vitreous, Retina, Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York.

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Multifocal choroiditis, an inflammatory eye condition, was observed in two sisters. This case series suggests a potential genetic or environmental link, warranting further investigation into the disease

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Area of Science:

  • Ophthalmology
  • Genetics
  • Immunology

Background:

  • Multifocal choroiditis (MFC) is an inflammatory disorder affecting the inner choroid and retinal pigment epithelium.
  • The etiology of MFC remains largely unknown.
  • Familial cases of MFC have not been previously reported.

Purpose of the Study:

  • To describe the clinical presentation of multifocal choroiditis in two siblings.
  • To investigate potential familial aggregation of multifocal choroiditis.

Main Methods:

  • Retrospective case reports.
  • Analysis of clinical findings in two affected sisters presenting a decade apart.

Main Results:

  • Both sisters presented with unilateral multifocal choroiditis.
  • The first sister showed late-stage findings with chorioretinal lesions and a scar.
  • The second sister exhibited acute inflammation with characteristic lesions and choroidal neovascularization.

Conclusions:

  • The occurrence of multifocal choroiditis in two sisters suggests a possible genetic or environmental influence.
  • Further research is needed to understand the underlying causes of multifocal choroiditis.