Related Experiment Video
Updated: Apr 21, 2026

07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
13.5K
Methicillin-resistant Staphylococcus aureus infectious scleritis after vitrectomy for endophthalmitis
Stephen J Kim1, Bryan J Schwent, Sunil K Srivastava
1From the Department of Ophthalmology, Emory University, Atlanta, Georgia.
Retinal Cases & Brief Reports
|November 13, 2014
Summary
Methicillin-resistant Staphylococcus aureus (MRSA) infectious scleritis is a serious complication following vitrectomy for endophthalmitis. Prompt, multi-route antibiotic treatment is crucial for resolution, though visual recovery may be limited.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Surgical Complications
Background:
- Endophthalmitis is a severe intraocular infection often requiring vitrectomy.
- Postoperative infections can significantly impact visual outcomes.
- Methicillin-resistant Staphylococcus aureus (MRSA) presents a growing challenge in healthcare settings.
Purpose of the Study:
- To report a rare case of MRSA infectious scleritis.
- To detail the management of this complication after vitrectomy for endophthalmitis.
Main Methods:
- Retrospective chart review of a single patient.
- Analysis of antecedent history, clinical course, treatment response, and visual acuity.
Main Results:
- Successful resolution of MRSA infectious scleritis was achieved.
- Treatment required a combination of systemic, periocular, intraocular, and topical antibiotics.
- Visual recovery was ultimately limited despite aggressive treatment.
Conclusions:
- MRSA infectious scleritis is a potential complication of vitrectomy for endophthalmitis.
- Resolution necessitates prolonged, multi-route antibiotic administration.
- Increased awareness and preventive strategies are vital to reduce the incidence of this severe complication.
Related Concept Videos
Staphylococcal Skin Infections
118
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
118
Microbiome of the Eye
62
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
62

