Macular hole associated with sarcoidosis
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Updated: Apr 21, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Le Yu1, Irena Tsui, Jean-Pierre Hubschman
1Retina Division, Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Purpose:
To describe an interventional case report of macular hole associated with sarcoidosis.
Methods:
A 63-year-old African American woman presented with unilateral decreased vision in the right eye. Clinical examination, ultra wide-field fluorescein angiography, and optical coherence tomography revealed a macular hole in the setting of intraocular inflammation. Pars plana vitrectomy was performed to close the macular hole, and a vitreous biopsy was performed.
Results:
The patient had closure of the macular hole and tissue confirmation of ocular sarcoidosis by vitreous biopsy.
Conclusion:
Macular hole associated with sarcoidosis is exceedingly rare. Surgical intervention may be necessary to close the macular hole and improve vision.
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