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Updated: Apr 21, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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Nuclear hormone receptors PXR and CAR and metabolic diseases

Li Mo, Jinhan He

    Hormone Molecular Biology and Clinical Investigation
    |November 13, 2014
    PubMed

    Insights

    Nuclear receptors (NRs) are proteins that regulate genes. This chapter explores xenobiotic receptors and their role in metabolic diseases, highlighting their newly discovered functions.

    Area of Science:

    • Molecular Biology
    • Endocrinology
    • Metabolism

    Background:

    • Nuclear receptors (NRs) are a superfamily of DNA-binding transcription factors.
    • They are activated by hormones and lipid metabolites, regulating gene expression.
    • NRs play crucial roles in various physiological and metabolic processes.

    Purpose of the Study:

    • To focus on xenobiotic receptors within the NR superfamily.
    • To discuss the recently discovered functions of these receptors in metabolic diseases.

    Main Methods:

    • This chapter focuses on a review of existing literature and research on nuclear receptors.
    • Analysis of gene regulation mechanisms controlled by ligand-activated NRs.
    • Examination of the role of xenobiotic receptors in metabolic disease pathways.

    Main Results:

    • Nuclear receptors bind to DNA response elements to modulate target gene expression.
    • Xenobiotic receptors, a subset of NRs, have emerging roles in metabolic regulation.
    • These receptors are increasingly implicated in the pathophysiology of metabolic disorders.

    Conclusions:

    • Nuclear receptors are key regulators of gene expression with broad physiological impact.
    • Xenobiotic receptors present novel therapeutic targets for metabolic diseases.
    • Further research into NR functions can illuminate metabolic disease mechanisms.

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