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Updated: Jul 31, 2026
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
Published on: August 4, 2011
Diffuse infiltrating anterior retinoblastoma in a 16-year-old boy
Jerry A Shields1, Ralph C Eagle, Carol L Shields
1From the *Oncology Service and the †Pathology Department, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; and the ‡Department of Ophthalmology, Dean A. McGee Eye Institute, University of Oklahoma, Oklahoma City.
Purpose:
To report an anterior diffuse infiltrating retinoblastoma in a teenager with a positive titer for toxocariasis.
Methods:
Clinical evaluation, enucleation and description of pathology.
Results:
The patient had a relatively flat, white lesion near the equator of the globe, with tumor seeding in the ciliary body, zonule and in the anterior chamber. Diffuse infiltrating retinoblastoma was suspected clinically and confirmed histopathologically after enucleation.
Conclusion:
Retinoblastoma can occur in a teenager who has a positive toxocara titer. The characteristic features should suggest the diagnosis of retinoblastoma, despite the patient's age.
