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Retinal vascular occlusion during in vitro fertilization
Byung-Ro Lee1, Yoo Mi Song, Igor Kozak
1From the *Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea; and †Department of Ophthalmology, University of California San Diego, Shiley Eye Center, La Jolla, California.
Retinal Cases & Brief Reports
|November 13, 2014
Summary
A case of retinal vascular occlusion occurred in a woman undergoing in vitro fertilization. This condition, involving retinal vein and artery occlusion, can happen during controlled ovarian hyperstimulation.
Area of Science:
- Ophthalmology
- Reproductive Medicine
Background:
- In vitro fertilization (IVF) involves controlled ovarian hyperstimulation.
- Gonadotropin-releasing hormone agonists are used in some IVF protocols.
Purpose of the Study:
- To report a case of retinal vascular occlusion in a patient undergoing IVF treatment.
- To highlight a potential complication of controlled ovarian hyperstimulation.
Main Methods:
- A case report of a 30-year-old woman experiencing vision loss.
- Diagnostic methods included fundoscopy and fluorescein angiography.
Main Results:
- The patient developed central retinal vein occlusion and branch retinal artery occlusion in her left eye.
- Fundoscopy showed hemorrhages and macular swelling; angiography confirmed the occlusions.
- Vision improved to 20/32 with retinal recovery after six months.
Conclusions:
- Retinal vascular occlusion is a potential risk during controlled ovarian hyperstimulation with gonadotropin-releasing hormone agonists.
- Ophthalmologists and fertility specialists should be aware of this association.

