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Immunohistochemical expression of TGF-β1 in lichen planus
Hala S El-Rebey1, Alaa H Maree, Samar El-Salakawy
1Departments of *Pathology †Dermatology and Andrology, Faculty of Medicine, Menofia University, Shebin El Kom, Egypt.
Background:
Lichen planus (LP) is a chronic recurrent rash of unknown cause with no established cure. Clinical and immunohistochemical studies strongly support an immunologic basis for the disease. There has been growing evidence suggesting a role for transforming growth factor β1 (TGF-β1) in the pathogenesis of LP.
Objective:
The aim of the present study was to investigate the possible role of TGF-β1 in the pathogenesis of LP.
Materials And Methods:
TGF-β1 was analyzed on skin biopsies of 25 patients presenting with LP and 10 age-matched and sex-matched normal subjects (controls).
Results:
TGF-β1 was expressed in keratinocytes of 70% of the control group and 48% of LP cases with a significant difference in intensities of expression (P=0.01). In LP, moderate intensity of keratinocyte expression was significantly associated with frequent apoptosis (P=0.04). Dermal lymphocytes showed positive expression in 80% and intense expression was significantly associated with absent hyperkeratosis (P=0.03). Only 2 cases showed mild expression in epidermal lymphocytes.
Conclusions:
Reduced TGF-β1 expression in LP may participate in immune dysregulation of the disease.
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