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The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
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Endocarditis III: Medical Management01:18

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Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Related Experiment Video

Updated: Apr 21, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Polymicrobial endogenous endophthalmitis.

Kiyofumi Mochizuki1, Toshihiko Katada, Hideaki Kawakami

  • 1From the *Department of Ophthalmology, JA Gifu Koseren, Chuno General Hospital, Gifu, the †Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, and the ‡Division of Anaerobe Research, Life Science Research Center, Gifu University, Division of Anaerobe Research, Gifu, Japan.

Retinal Cases & Brief Reports
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Summary

This case study highlights polymicrobial endogenous endophthalmitis caused by group G Streptococcus and Staphylococcus capitis. Prompt treatment with antibiotics and vitrectomy led to visual recovery.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases

Background:

  • Endogenous endophthalmitis is a severe intraocular infection.
  • Polymicrobial infections can present unique diagnostic and therapeutic challenges.

Purpose of the Study:

  • To report a rare case of polymicrobial endogenous endophthalmitis.
  • To identify the causative organisms and outline successful management strategies.

Main Methods:

  • Standard ophthalmologic examinations.
  • Blood and vitreous fluid cultures for microbial identification.
  • Treatment with broad-spectrum antibiotics and pars plana vitrectomy with intravitreal antibiotic administration.

Main Results:

  • A 72-year-old woman presented with uveitis.
  • Blood cultures revealed group G Streptococcus and coagulase-negative staphylococcus.
  • Vitreous cultures identified group G Streptococcus and Staphylococcus capitis.
  • Successful resolution of uveitis and restoration of best-corrected visual acuity to 20/20 at 6 months post-treatment.

Conclusions:

  • Group G Streptococcus and Staphylococcus capitis can cause polymicrobial endogenous endophthalmitis.
  • Early and aggressive management involving systemic antibiotics, vitrectomy, and intravitreal antibiotics is crucial for favorable outcomes.