Polymicrobial endogenous endophthalmitis
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Updated: Apr 21, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Kiyofumi Mochizuki1, Toshihiko Katada, Hideaki Kawakami
1From the *Department of Ophthalmology, JA Gifu Koseren, Chuno General Hospital, Gifu, the †Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, and the ‡Division of Anaerobe Research, Life Science Research Center, Gifu University, Division of Anaerobe Research, Gifu, Japan.
Purpose:
We report a case of polymicrobial endogenous endophthalmitis caused by group G streptococcus and Staphylococcus capitis.
Methods:
Standard ophthalmologic examinations.
Results:
A 72-year-old woman presented with signs of uveitis. Treatment with broad-spectrum antibiotics was prescribed, and vitrectomy with intravitreal antibiotic administration was then performed. Blood cultures were positive for group G streptococcus and coagulase-negative staphylococcus. Cultures of vitreous aspirate yielded group G streptococcus and S. capitis. Uveitis was resolved with antibiotic treatment and vitrectomy, with best-corrected visual acuity of 20/20 at 6 months.
Conclusions:
Endogenous endophthalmitis can be caused by two intravitreal organisms (e.g., group G streptococcus and S. capitis). Early treatment with broad-spectrum antibiotics and vitrectomy with intravitreal injections of antibiotic might be considered in similar cases.
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