Related Experiment Video
Updated: Apr 21, 2026
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
Published on: August 4, 2011
Anterior segment retinoblastoma detectable on magnetic resonance imaging
M Vaughn Emerson1, Norman Saffra, Les Saint Louis
1From the *Retina Center, Minneapolis, Minnesota; †Maimonades Hospital, Brooklyn, New York; ‡Corinthian Diagnostic Radiology, New York, New York; §Department of Pathology, University of Illinois Medical Center at Chicago, Chicago, Illinois; Departments of ¶Biomedical Sciences, **Pathology, and ††Ophthalmology, Oakland University William Beaumont School of Medicine, Rochester, Michigan; and ‡‡Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.
Purpose:
To report a case of retinoblastoma infiltrating the iris and ciliary body detected on magnetic resonance imaging.
Methods:
A retrospective case report with clinical evaluation, diagnostic testing, enucleation, and pathologic description.
Results:
A 2-year-old boy presented with hyphema and was noted to have a fluffy whitish iris mass. Retinoblastoma with anterior chamber extension was suggested on magnetic resonance imaging. T2-weighted images demonstrated a hypointense mass with a superficial layer of focal marked hypointensity, consistent with hemorrhage or calcification. Enucleation was performed, and histopathology confirmed retinoblastoma infiltrating the iris and ciliary body. No further treatment was administered, and the patient remains free of associated disease at age 5 years.
Conclusion:
Retinoblastoma can invade the iris and ciliary body stroma. The use of magnetic resonance imaging in evaluating cases of anterior segment masses can demonstrate findings suggestive of retinoblastoma.
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
01:24Magnetic Resonance Imaging