Related Experiment Video
Updated: Apr 21, 2026
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Improved perfusion and intraretinal neovascularization after intravitreal bevacizumab injection in central vein
Michelle Y Peng1, Margaret Chang, Howard S Ying
1Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Purpose:
To report a case of intraretinal neovascularization in a patient with ischemic central venous occlusion.
Methods:
Case report.
Results:
An 18-year-old white man presented with painless decreased vision in the right eye. Slit-lamp and biomicroscopic examinations revealed 360° of neovascularization of the iris, venous tortuosity, severe retinal hemorrhages, cotton wool spots, and massive edema of the macula.
Conclusion:
This is the first report of observed intraretinal neovascularization after central vein occlusion. Treatment with photocoagulation and intravitreal bevacizumab injection promoted revascularization after 1 year.
