Related Experiment Video
Updated: Apr 21, 2026
09:28
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Published on: September 16, 2020
9.6K
INTERFERON-β-ASSOCIATED RETINOPATHY
Javier S Martinez de Aragon1, Jose S Pulido, Christopher L Haupert
1From *the Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota; †Iowa Retina Consultants, West Des Moines, Iowa; and ‡the Department of Ophthalmology, Northwestern University, Chicago, Illinois.
Retinal Cases & Brief Reports
|November 13, 2014
Summary
Interferon-β treatment can cause retinopathy, a rare eye condition. Regular eye exams are recommended for patients on interferon-β to detect this complication early.
Area of Science:
- Ophthalmology
- Neurology
- Immunology
Background:
- Interferon-associated retinopathy is a rare adverse effect of interferon therapy.
- While well-documented with interferon-alfa, its occurrence with interferon-beta is less common.
Purpose of the Study:
- To describe interferon-beta-associated retinopathy.
- To highlight clinical findings and patient outcomes.
Main Methods:
- Retrospective case series.
- Analysis of three patients treated with interferon-beta for multiple sclerosis.
Main Results:
- Characteristic findings included cotton-wool spots and peripheral microaneurysms.
- One patient experienced central retinal artery occlusion.
- Two cases showed spontaneous improvement; all patients continued interferon-beta therapy.
Conclusions:
- Periodic funduscopic examinations are advised for patients on interferon-beta.
- Early detection of interferon-associated retinopathy is crucial.
Related Concept Videos
01:27Diabetic Retinopathy
11
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
11
01:30Inhibitors of Viral Protein Synthesis
47
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
47
01:20The Retinoblastoma Gene
5.0K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
5.0K