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Updated: Apr 21, 2026
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
Photodynamic therapy and vitrectomy for a large optic nerve hemangioma with neovascularization and retinal
Armando Alegret1, Colleen M Cebulla, Sander R Dubovy
1From the Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miller School of Medicine, and the Florida Lions Ocular Pathology Laboratory, Miami, Florida.
Purpose:
To report the clinicopathologic correlation of a young man with a von Hippel-Lindau disease-associated peripapillary hemangioblastoma and its satisfactory response to a combination of photodynamic therapy (PDT) and vitrectomy.
Design:
Clinicopathologic correlation.
Methods:
We studied the case of a 14-year-old boy with an optic nerve mass and large inferior exudative retinal detachment complicated by a significant tractional component from extensive secondary neovascularization over the lesion.
Results:
A juxtapapillary hemangioblastoma with secondary neovascularization was documented by clinical examination, fundus photography, and optical coherence tomography. A von Hippel-Lindau gene mutation was detected. The patient responded satisfactorily to a combination of PDT and vitrectomy.
Conclusions:
A staged approach to treatment of peripapillary hemangioblastoma with a combination of PDT and vitrectomy may be favorable to therapy with one modality.
