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Updated: Apr 21, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Interferon induced sarcoid uveitis with papillitis and macular edema
Nitin Nigam1, Joshua Hedaya, W R Freeman
1From the UCSD Department of Ophthalmology, Shiley Eye Center, La Jolla, California.
Purpose:
To describe the ocular manifestations of interferon induced sarcoidosis.
Methods:
Observational case report.
Results:
A 42-year-old woman with hepatitis C developed papillitis and macular edema together with cutaneous lesions 3 months after starting interferon and ribavirin therapy. The therapy was stopped. After 17 months of observation, visual acuity remained stable and papillitis and macular edema persisted. The patient was finally treated with sub-tenon's repository methyl prednisolone in the left eye which significantly resolved both macular edema and papillitis and also improved vision.
Conclusion:
Interferon induced sarcoidosis is a new entity and can have ocular manifestations such as uveitis and papillitis as one of the presenting features, which is not common.
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