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Published on: December 7, 2016
Regression of choroidal neovascularization after vitrectomy for postinjection endophthalmitis
Hirofumi Emoto1, Yuko Emoto, Jennifer I Lim
1From the *Department of Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan; †Department of Neuro-Ophthalmology, Inouye Eye Hospital, Tokyo, Japan; ‡Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois; §Doheny Eye Institute, University of Southern California, Los Angeles, California; and ¶VMR Institute, Huntington Beach, California.
Purpose:
To report regression of choroidal neovascularization following vitrectomy for endophthalmitis after antivascular endothelial growth factor injections.
Methods:
Observational case series of two patients with exudative age-related macular degeneration.
Results:
Endophthalmitis developed 2 days after the fourth ranibizumab injection in 1 case and 1 day after the ninth bevacizumab injection in another case. Vitrectomy and intravitreal antibiotic injections were performed. There was no bacterial growth on the cultures. Postoperative fluorescein angiography and combined optical coherence tomography/scanning laser ophthalmoscopy showed regression of choroidal neovascularization that was sustained after 29 and 32 months follow-up.
Conclusion:
In both patients with active exudative age-related macular degeneration, regression of choroidal new vessels occurred after vitrectomy and injection of intravitreal antibiotics for the treatment of endophthalmitis. Removal of the posterior vitreous during vitrectomy may have eliminated the contribution of vitreous to exudative age-related macular degeneration and choroidal neovascularization.
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