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Updated: Apr 21, 2026
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
Resolution of a giant pigment epithelial detachment after treatment with intravitreal bevacizumab
Jon D Wender1, Robert N Johnson, Richard H Roe
1From the Retina Research Fund of St. Mary's Medical Center, San Francisco, and the Pacific Vision Foundation, California Pacific Medical Center, San Francisco, California.
Purpose:
To describe a patient with a giant pigment epithelial detachment (PED) successfully treated with intravitreal bevacizumab.
Design:
Retrospective, observational case report.
Methods:
The patient's records were reviewed.
Results:
An 81-year-old man with history of age-related macular degeneration was seen on routine follow-up examination with an asymptomatic PED temporal to the macula in the right eye and visual acuity of 20/40. The patient was observed. Ten months later, the patient was found to have decreased vision to 20/80 and massive enlargement of the PED, with extension from the temporal equator into the macula. Optical coherence tomography of the macula showed a PED with overlying intraretinal cysts. The patient was given injections of intravitreal bevacizumab for every 4 months (1.25 mg) with complete resolution of the PED and return to baseline visual acuity of 20/40.
Conclusion:
Giant PED secondary to exudative age-related macular degeneration can be successfully treated with intravitreal bevacizumab.
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