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DNA fragments which specifically bind to isolated nuclear matrix in vitro interact with matrix-associated DNA
Y S Vassetzky1, S V Razin, G P Georgiev
1Institute of Molecular Biology, USSR Academy of Sciences, Moscow.
Biochemical and Biophysical Research Communications
|March 31, 1989
Abstract:
A matrix-associated region (MAR)-containing fragment has been selected from the library of cloned chicken nuclear matrix-associated DNA fragments. Factors, which determine the specific binding of DNA fragments have been studied. Using topoisomerase II-specific inhibitor VM 26 we established that nuclear matrix-associated topoisomerase II interacted with the MAR-containing DNA fragment producing specific cleavage sites on DNA of the fragment.