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Related Concept Videos

Preparation of Samples for Electron Microscopy01:20

Preparation of Samples for Electron Microscopy

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To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...
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Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
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Miniaturized Sample Preparation for Transmission Electron Microscopy
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Newly introduced sample preparation techniques: towards miniaturization.

Rosaria Costa1

  • 1a Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute (SCIFAR) , University of Messina , Messina , Italy.

Critical Reviews in Analytical Chemistry
|November 14, 2014
PubMed
Summary
This summary is machine-generated.

Accurate chemical analysis relies on effective sample preparation techniques. This study reviews modern methods addressing miniaturization, sensitivity, selectivity, and automation needs for improved analytical results.

Keywords:
Miniaturized techniquespreconcentrationsample preparationsampling

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Area of Science:

  • Analytical Chemistry
  • Chemical Analysis
  • Sample Preparation

Background:

  • Sample preparation is critical in analytical procedures and a common source of errors.
  • Analyte isolation techniques significantly impact the success of chemical determinations.
  • Environmental and safety concerns, plus quality control regulations, drive new sample preparation needs.

Purpose of the Study:

  • To survey and discuss recent advancements in sample preparation techniques.
  • To highlight methods meeting new criteria: miniaturization, higher sensitivity and selectivity, and automation.
  • To provide examples of applications for these emerging techniques.

Main Methods:

  • Review of recent literature on sample preparation methodologies.
  • Discussion of techniques focusing on miniaturization, sensitivity, selectivity, and automation.
  • Inclusion of diverse application examples to illustrate technique utility.

Main Results:

  • Identification of several novel sample preparation techniques.
  • Demonstration of how these techniques address contemporary analytical challenges.
  • Examples showcase improved efficiency, accuracy, and reduced environmental impact.

Conclusions:

  • Modern sample preparation techniques are essential for advancing analytical chemistry.
  • The discussed methods offer solutions for miniaturization, enhanced sensitivity/selectivity, and automation.
  • These advancements are crucial for meeting current environmental, safety, and quality control standards.