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Oocyte ageing and epigenetics.

Zhao-Jia Ge1, Heide Schatten2, Cui-Lian Zhang3

  • 1Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA.

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Summary
This summary is machine-generated.

Female fertility declines with age due to compromised oocyte quality. This review explores how aging impacts oocyte quality, focusing on epigenetic changes and their reproductive implications.

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Area of Science:

  • Reproductive biology
  • Epigenetics
  • Aging research

Background:

  • Delayed childbearing is a growing social trend.
  • Advanced maternal age is associated with reduced oocyte quality and lower pregnancy rates.
  • Understanding age-related oocyte quality decline is crucial for reproductive health.

Purpose of the Study:

  • To summarize the effects of aging on oocyte quality.
  • To discuss the relationship between female aging and epigenetic modifications.
  • To highlight epigenetic changes in oocytes from older females and post-ovulatory aged oocytes.

Main Methods:

  • Literature review focusing on aging, oocyte quality, and epigenetics.
  • Analysis of mechanisms underlying age-related epigenetic changes in oocytes.
  • Discussion of potential factors influencing epigenetic reprogramming in germ cells.

Main Results:

  • Aging negatively affects oocyte quality through mitochondrial dysfunction, aneuploidy, and epigenetic alterations.
  • Epigenetic modifications are crucial for oogenesis and early embryonic development.
  • Improper epigenetic changes can occur due to internal and external factors and may be heritable.

Conclusions:

  • Age-related epigenetic changes in oocytes contribute to reduced fertility in older women.
  • Further research into these epigenetic mechanisms is needed to improve reproductive outcomes.
  • Understanding these changes can inform strategies for managing age-related fertility decline.