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Updated: Apr 21, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
Published on: April 12, 2024
First description of pharmacoresistant epilepsy due to independent bilateral hypothalamic hamartomas
Anke Maren Staack1, Karl Strobl, Julia Scholly
1Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany, astaack@epilepsiezentrum.de.
Abstract:
Hypothalamic hamartomas (HHs) are rare developmental malformations consisting of mixed neurons and glial cells, usually unilaterally attached to the tuber cinereum or mammillary bodies. We report on two patients, both suffering from pharmacoresistant epilepsy, behavioural and cognitive disturbances. Ictal and interictal electroencephalographic (EEG) abnormalities appeared bilaterally and multiregionally with right-sided preponderance. Magnetic-resonance imaging (MRI) revealed independent bilateral hypothalamic hamartomas, more prominently on the right side. Endoscopic surgery of the right HH was performed in each patient, resulting in a significant seizure reduction in both cases. To the best of our knowledge, there are no other reports of independent bilateral HHs in the literature.
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