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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Dynamic changes of the various cytokines following carotid artery stenting
1Department of Neurology, No. 264 Hospital, Taiyuan, Shanxi Province, China. jiating814@sina.com.
Insights
Carotid artery stenting increases serum inflammatory markers like hs-CRP and IL-6, and coagulation factors such as fibrinogen and D-dimer. These changes are significant for monitoring postoperative complications after the procedure.
Area of Science:
- Cardiovascular Medicine
- Clinical Chemistry
- Biomarker Research
Background:
- Carotid artery stenting (CAS) is a crucial intervention for preventing stroke.
- Understanding the systemic inflammatory and coagulation response post-CAS is vital for patient management.
Purpose of the Study:
- To investigate the dynamic changes in serum inflammatory and coagulation factors after CAS.
- To assess the clinical significance of these factors in monitoring postoperative complications.
Main Methods:
- Serum levels of IL-2, IL-6, IL-8, sICAM-1, hs-CRP, TNF-α, PT, APTT, FIB, DD, and FDP were measured in 92 CAS patients.
- Measurements were taken pre-procedure and at 24h, 48h, 3 days, and 1 week post-procedure.
- A control group of 92 subjects undergoing angiography without stenting was included for comparison.
Main Results:
- CAS significantly elevated hs-CRP, TNF-α, sICAM-1, IL-6, IL-8, FIB, and DD post-surgery (p < 0.05).
- hs-CRP peaked at 48h; TNF-α, sICAM-1, and IL-6 remained elevated for 3-7 days.
- FIB and DD showed increases at 48h and 3 days, respectively.
- CAS group exhibited higher levels of hs-CRP, TNF-α, sICAM-1, IL-8, FIB, and DD compared to the angiography group.
Conclusions:
- Post-CAS, significant increases in hs-CRP, TNF-α, sICAM-1, IL-8, FIB, and DD were observed.
- These biomarkers are valuable for monitoring acute postoperative complications following carotid artery stenting.
Objective:
To observe the serum inflammatory and coagulation factors changes and clinical significance following carotid artery stenting.
Patients And Methods:
The expressions of serum inflammatory factors including IL-2, IL-6, IL-8, sICAM-1, hs-CRP, and TNF-α and serum coagulation factors including prothrombin time (PT), active partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (DD), and fibrin degradation products (FDP) were determined in 92 patients who had undergone carotid artery stenting before, 24h, 48 h, 3 days and 1 week after the surgery. As well, 92 subjects who did not receive stenting were enrolled in the angiography group, amongst whom the same variables were determined.
Results:
In the stenting group, the expressions of hs-CRP, TNF-α, sICAM-1, IL-6, IL-8, FIB, and DD were significantly increased after the surgery (p < 0.05): hs-CRP reached a peak 48 h after the surgery; TNF-α, sICAM-1, and IL-6 maintained at high levels at days 3-7; and FIB and DD increased 48 h and 3d after the surgery. Compared with the angiography group, the expressions of hs-CRP, TNF-α, sICAM-1, and IL-8 (24h after the surgery) as well as FIB and DD (48 h and 3d after the surgery) were significantly higher in the stenting group.
Conclusions:
The hs-CRP, TNF-α, sICAM-1, IL-8, FIB, and DD increased after carotid artery stenting and, therefore, can serve as important factors for monitoring for acute postoperative complications.
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