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Resveratrol improves high-fructose-induced vascular dysfunction in rats
Seval Develi-Is1, Gulsev Ozen, Seldag Bekpinar
1a Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa 34093, Istanbul, Turkey.
Canadian Journal of Physiology and Pharmacology
|November 14, 2014
Summary
Resveratrol (RES) improves high-fructose diet-induced vascular dysfunction in rats by restoring arginine levels and influencing key aortic gene expressions. This suggests RES benefits vasculature, partly by modulating SIRT1, GLUT5, and aldolase B.
Area of Science:
- Biochemistry
- Cardiovascular Physiology
- Nutritional Science
Background:
- High fructose intake is linked to metabolic abnormalities and vascular disorders.
- Diet-induced vascular dysfunction involves altered relaxation and contraction responses.
Purpose of the Study:
- To investigate the effects of resveratrol (RES) on vascular function in rats fed a high-fructose (HFr) diet.
- To examine the impact of RES on aortic gene expression, including sirtuin 1 (SIRT1), GLUT5, and aldolase B.
Main Methods:
- Rats were administered fructose (30%) and/or RES (50 mg/L) in drinking water for 8 weeks.
- Vascular relaxation and contraction responses were assessed in aortic rings.
- mRNA expressions of aortic SIRT1, GLUT5, and aldolase B were quantified.
Main Results:
- HFr feeding decreased plasma arginine and the arginine:ADMA ratio, increased leptin, and impaired aortic relaxation.
- RES treatment restored vascular function, increased plasma arginine and the arginine:ADMA ratio, and decreased leptin.
- RES increased aortic SIRT1 expression while decreasing GLUT5 and aldolase B expression in HFr-fed rats.
Conclusions:
- Resveratrol ameliorates high-fructose-induced vascular dysfunction in rats.
- The protective effects of RES involve up-regulation of SIRT1 and down-regulation of GLUT5 and aldolase B in the aorta.
- RES positively influences vasculature by restoring plasma arginine:ADMA ratio and leptin levels.
